Hydrochloric Acid → 3-(Acetylamino)-2-[1,1'-biphenyl]-4-yl-6-fluoro-4-quinolinecarboxylic acid

Participants

Reaction Steps

A 1.8 g portion of 5-[1,1'-biphenyl]-4-yl-9-fluoro-3-methyl-1H-[1,3]oxazino[4,5-c]quinolin-1-one was dissolved in 50 ml of tetrahydrofuran. To this was added 10 ml of water containing 0.94 ml of 1N sodium hydroxide. This mixture was stirred for 4 hours, then poured into 500 ml of water and acidified to pH 4 with 3% aqueous hydrochloric acid. The resulting solid was collected, washed with water and dried at 110° C. in vacuo, giving 1.6 g of the desired product as a white solid mp 256°-259° C.

Provenance & Evidence