Water → 3-(Acetylethylamino)-2-[1,1'-biphenyl]-4-yl-6-fluoro-4-quinolinecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

A 2.8 g portion of 2-[1,1'-biphenyl]-4-yl-3-(ethylamino)-6-fluoro-4-quinolinecarboxylic acid was suspended in 25 ml of acetic anhydride. To this suspension was added 5 drops of concentrated sulfuric acid, then the mixture was heated at 80° C. for 2 hours. The solution was cooled, added to 200 ml of water and stirred for 30 minutes. The resulting solid was collected, washed with water, then dichloromethane and dried at 110° C. in vacuo, giving 2.0 g of the desired product as a pale yellow solid, mp 260°-262° C.

Provenance & Evidence