Sodium Hydroxide → HCID 15085962, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 526 mg of 5-fluoroisatin in 4 ml of water was added 737 mg of sodium hydroxide in 6 ml of water. The resulting solution was heated to 80° C., then a solution of 1.254 g of 2-amino-1-[4-(phenylthio)phenyl]ethanone, hydrochloride in 8 ml of ethanol and 8 ml of water was added dropwise. After heating at reflux for 1 hour, the volatiles were removed in vacuo, 10 ml of water was added and the mixture filtered. A 60 ml portion of water was added to the filtrate which was then acidified to pH 4 with glacial acetic acid. After stirring for 25 minutes the solid was collected, washed with water and crystallized from 50 ml of hot acetonitrile, giving 442 mg of the desired product, mp 219°-221° C. (dec.).

Provenance & Evidence