HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Amino-6-trifluoromethyl-2-(4-phenoxyphenyl)-4-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 5-(trifluoromethyl)-2,3-dihydro-1H-indole-2,3-dione | HCID 12351496 | — |
| Reactant | 2-Amino-4'-phenoxyacetophenone hydrochloride | HCID 22158350 | — |
| Product | 3-Amino-6-trifluoromethyl-2-(4-phenoxyphenyl)-4-quinolinecarboxylic acid | HCID 15085964 | — |
Reaction Steps
A solution of 6.45 g of 5-trifluoromethylisatin in water was reacted with 7.91 g of 2-amino-4'-phenoxyacetophenone hydrochloride (example 5) by the procedure described in example 6, giving 7.7 g of the desired compound as a yellow solid, mp 220°-225° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04968702 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-ac47184de50e4df799851d4f962bbaed |
| Source note | uspto-grants-1990_11 |