(3R)-pyrrolidin-3-amine → cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)

(3R)-3-Aminopyrrolidine (400 mg) prepared in Reference Example 1-(3) is dissolved in water (200 ml) and thereto is added platinum (II) potassium chloride (2.0 g), and the mixture is stirred at room temperature for 20 hours. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added water (3 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) (1.28 g) as pale yellow crystal. The physical properties of the cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) thus obtained are identical with those of the cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) as obtained in the above (1-A).

1. customThe precipitated solid is removed by filtration
2. concentrationthe filtrate is concentrated under reduced pressure
3. additionTo the residue is added water (3 ml)
4. customthe resulting crystals are separated by filtration
5. washwashed with water and acetone

ORD record

ord-8e246e4f8fff4a2a815ce0f0c3a921cf

Source dataset

uspto-grants-1990_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04968800