Sodium Hydroxide → HCID 18640048, compound

HRID 1073314Notes

Reaction equation

HRID 1073314 reaction equation
C([C@@H]([C@H](C(O)=O)O)O)(O)=O.[NH2:11][C@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@H:13]1[C@@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 86744074platinum (II) potassium chlorideHCID 86744075HCID 86744075, compound

Product 1

HCID 18640048HCID 18640048, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(3S)-3-Aminopyrrolidine L(+)-tartrate (236 mg) prepared in Reference Example 1-(2) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated to dryness under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3S)-3-aminopyrrolidine platinum (II) (221 mg) as pale yellow crystal.

Workup

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated to dryness under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

Sources & evidence

ORD record
ord-bfa27fc0ea7b4abb8b60697e553fe70d
Source dataset
uspto-grants-1990_11
Patent number
US04968800

Reaction notes

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