Piperidin-3-amine → HCID 86744076, 화합물

HRID 1073315노트

반응식

HRID 1073315 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][NH:4][CH2:3]1.[Cl-:8].[K+].[Pt+2:10].[Cl-:11].[Cl-]>O>[Pt+2:10].[Cl:8][C@H:3]1[C@@H:2]([NH2:1])[CH2:7][CH2:6][CH2:5][N:4]1[Cl:11]

참가 물질

4

반응물 2

HCID 148119Piperidin-3-amineHCID 86744074platinum (II) potassium chloride

생성물 1

HCID 86744076HCID 86744076, 화합물수율 69.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of (3RS)-3-aminopiperidine (1.7 g) in water (1000 ml) is added platinum (II) potassium chloride (7.2 g) and the mixture is stirred at room temperature for 40 hours. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added a small amount of water, and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3RS)-3-aminopiperidine platinum (II) (4.3 g) as pale yellow crystal.

후처리

  1. customThe precipitated solid is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. additionTo the residue is added a small amount of water
  4. customthe resulting crystals are separated by filtration
  5. washwashed with water and acetone

출처 및 근거

ORD 기록
ord-5165e30298ff43a4aedc049b5a87f98f
출처 데이터셋
uspto-grants-1990_11
특허 번호
US04968800

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