3-Aminopyrrolidine → (3R)-3-Aminopyrrolidine D(-)-tartrate

Participants

Reaction Steps

D(-)-tartaric acid (17 g) is dissolved in a mixture of water (30 ml) and methanol (120 ml), and to the solution is gradually added (3RS)-3-aminopyrrolidine (19 g), and the mixture is stirred. When exothermic reaction is finished, methanol (60 ml) is added to the mixture, and the mixture is allowed to stand at 0°-2° C. overnight. The precipitated crude (3R)-3-aminopyrrolidine D(-)-tartrate (20.6 g) is taken by filtration. This product is recrystallized from a mixture of methanol-water (2:3) four times to give (3R)-3-aminopyrrolidine D(-)-tartrate (6.8 g).

Provenance & Evidence