5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 67860895, compound

Participants

Reaction Conditions

Reaction Steps

21·4 g (0·1 mol) of 2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamine and 35·1 g (0·1 mol) of 1,1,1-triphenoxy-2-nitroethane are boiled for 3 hours in 250 ml of acetonitrile under a nitrogen atmosphere. The solvent is evaporated off under vacuum after cooling to 40° C. and the yellow oil left behind is chromatographed on 560 g of silica gel with dichloromethane/methanol (95:5). After concentration by evaporation under vacuum, the main fraction yields 28·7 g (76%) of the title compound in the form of a yellowish, viscous oil.

Provenance & Evidence