HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1073366Generated: October 25, 2026
Water → 2,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol
https://huagongshe.com/reaction/1073366
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,1,1-Trichloro-2,2,2-trifluoroethane | HCID 9635 | — |
| Reactant | 2,6-Dichloro-4-nitrobenzaldehyde | HCID 21838835 | — |
| Reactant | HCID 178506323 | HCID 178506323 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,2-Dichloro-3,3,3-trifluoro-1-(2,6-dichloro-4-nitrophenyl)-1-propanol | HCID 14848519 | — |
Reaction Steps
3 g of 2,6-dichloro-4-nitro benzaldehyde were reacted, in 20 ml of anhydrous DMF under a nitrogen atmosphere, with CF3CCl2ZnCl prepared from 5 g of CF3CCl3 and 2.2 g of Zn in 10 ml of THF at 60° C. for 1 hour. The mixture was heated at 50° C. for 2 hours and at the end of the reaction it was poured into acidulated water and extracted repeatedly with ethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04968847 |
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| Source dataset | uspto-grants-1990_11 |
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| ORD ID | ord-74c3d48a7dcf426eb8066870b97680eb |
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| Source note | uspto-grants-1990_11 |
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