4-(Trifluoromethyl)benzoic acid → 4-(Trifluoromethyl)benzoyl bromide

HRID 1073368Notes

Reaction equation

HRID 1073368 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][CH:4]=1.P(Br)(Br)[Br:15]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([Br:15])=[O:8])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 99664-(Trifluoromethyl)benzoic acidHCID 24614Phosphorus tribromide

Product 1

HCID 141533934-(Trifluoromethyl)benzoyl bromideYield 169.7%

Procedure

In a 50 ml glass reactor, 30 g of 4-trifluoromethylbenzoic acid and 14.5 g of phosphorus tribromide were reacted at 155° C. for 3 hr. After that the reaction liquid was distilled under reduced pressure to obtain 23 g of 4-trifluoromethylbenzoyl bromide having a boiling point of 88°-89° C. at 18 mmHg. The yield in this reaction was 58%.

Workup

  1. customAfter that the reaction liquid
  2. distillationwas distilled under reduced pressure

Sources & evidence

ORD record
ord-37debe9c721a41708dc79f130d3dd352
Source dataset
uspto-grants-1990_11
Patent number
US04968852

Reaction notes

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