Water → HCID 15662564, compound

Participants

Reaction Steps

To 2-[4-(3-methyl-2-butenoxy)phenoxy]propionitrile (2.0 g, 8.6 mmol) in 20 ml of ether is added lithium aluminum hydride (0.328 g, 8.6 mmol) in portions at 5°. After the addition, the reaction mixture is slowly warmed to RT and stirred for 18 hours. The reaction is worked up by cooling to 5° and by adding 0.33 ml of water, followed by 0.33 ml of 15% NaOH and 1 ml of water, with vigorous stirring. The solid is filtered off and the filtrate is washed with brine and dried over calcium sulfate. The ether is removed to give 2-[4-(3-methyl-2-butenoxy)phenoxy]propylamine.

Provenance & Evidence