HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dimethylaminopyridine → 2,4-Dichloro-6-methyloxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,4-Dichloro-6-methoxybenzoic acid | HCID 13553317 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Dichloro-6-methyloxybenzoyl chloride | HCID 13794848 | 55% |
Reaction Steps
26.0 g. (0.117 mol) 2,4-Dichloro-6-methoxybenzoic acid were dissolved in 50 ml. anhydrous methylene chloride and, after the addition of 0.1 g. dimethylaminopyridine, 50 ml. thionyl chloride were added dropwise thereto at ambient temperature. After stirring for 15 hours, the reaction mixture was evaporated and the residue distilled. Yield: 55% of theory; b.p. 118-124° C./0.1 mm.Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04970077 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-54c91ab192824b9c8107ede9611926c7 |
| Source note | uspto-grants-1990_11 |