HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Benzyloxyindole → 5-Phenylmethoxy-1-(4-pyridinylamino)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Benzyloxyindole | HCID 14624 | — |
| Reactant | hydroxylamine-O-sulfonic acid | HCID 76284 | — |
| Reactant | 4-Chloropyridine hydrochloride | HCID 81852 | — |
| Reactant | 5-(Benzyloxy)-1H-indol-1-amine | HCID 14988297 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 5-Phenylmethoxy-1-(4-pyridinylamino)-1H-indole | HCID 14988282 | — |
Reaction Steps
The title compound was prepared from 5-benzyloxy-1H-indol-1-amine (which had been prepared from 5-benzyloxy-1H-indole and hydroxylamine-O-sulfonic acid in substantially the same manner as in Example 25) and 4-chloropyridine hydrochloride in N-methyl-2-pyrrolidinone at 70° C. for 1.5 hours in substantially the same manner as in Example 1, m.p. 143°-145° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04970218 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-7d9da1f2f0b34b50b34ee0489ffbda8f |
| Source note | uspto-grants-1990_11 |