反应详情

To 1 ml of toluene was added 0.1 g (0.35 mmol) of the product of Example 4, 0.11 g (0.38 mmol) of the product of Example 9, and 5.0 mg of tetrakis(triphenylphosphine)palladium(O). The solution was degassed with argon and then heated at reflux under argon for approximately 5 hours. The reaction mixture was then cooled to room temperature and flash chromatographed. Gradient elution with hexane, 1% diethyl ether in hexane, 5% diethyl ether in hexane, and 10% diethyl ether in hexane produced 0.90 mg (0.19 mmol) of the titled product.

1. customThe solution was degassed with argon
2. temperatureheated
3. temperatureat reflux under argon for approximately 5 hours
4. customflash chromatographed
5. washGradient elution with hexane, 1% diethyl ether in hexane, 5% diethyl ether in hexane