2,6-Dimethylpiperazine → HCID 67925873, compound

Participants

Reaction Steps

The reaction is carried out under the conditions of Reference Example 3 but starting from 1.7 g of 8-chloro-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid and 2.5 g of 2,6-dimethylpiperazine in 20 cm3 of pyridine. 1.1 g of 8-(3,5-dimethyl-1-piperazinyl)-7-fluoro-1-methyl-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid hemihydrate are obtained in the form of a yellow solid melting at 294°-295° C.

Provenance & Evidence