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A solution of 19.02 g. of benzoylthiourea and 19.12 g. of ethyl bromopyruvate in 300 ml. of ethanol was refluxed for 2 hours. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (1 liter) and 20% aqueous sodium carbonate (400 ml.). The organic layer was separated, washed successively with 20% aqueous sodium carbonate (3×400 ml.), water (2×400 ml.) and a brine solution (2×400 ml.) and dried over sodium sulfate. The solution was concentrated to about 50 ml. and the precipitated solids filtered and dried, 20.16 g., m.p. 146-147° C.

1. customThe solvent was removed in vacuo
2. customthe residue partitioned between ethyl acetate (1 liter) and 20% aqueous sodium carbonate (400 ml.)
3. customThe organic layer was separated
4. washwashed successively with 20% aqueous sodium carbonate (3×400 ml.), water (2×400 ml.)
5. dry with materiala brine solution (2×400 ml.) and dried over sodium sulfate
6. concentrationThe solution was concentrated to about 50 ml
7. filtrationand the precipitated solids filtered
8. customdried