HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 1alpha-Methyl-6-methylenandrost-4-ene-3,17-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-Methylaniline | HCID 7515 | — |
| Reactant | 4-Androstene-3,17-dione, 1alpha-methyl- | HCID 10957561 | — |
| Reactant | Diethylorthoformate | HCID 86744342 | — |
| Product | 1alpha-Methyl-6-methylenandrost-4-ene-3,17-dione | HCID 18642031 | 75% |
Reaction Steps
With a procedure similar to the one described in Example 1, 3 g of 1α-methylandrost-4-ene-3,17-dione, 3 ml of diethylorthoformate, 80 mg of p-toluenesulphonic acid, 1.1 ml of N-methylaniline and 1,2 ml of a 40% formic aldehyde aqueous solution give 2.34 g (75% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04970327 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-cb1ac60841654525870d718055b1d742 |
| Source note | uspto-grants-1990_11 |