L-Tartaric acid → HCID 178523846, compound

Participants

Reaction Steps

To a solution of (3S)-1,3-dihydro-1-(4-imidazolylmethyl) -3-(2-indolylcarbonylamino)-5-(2-fluorophenyl) -2H-1,4-benzodiazepine-2-one (246 mg) in methanol (10 ml) was added L-(+)-tartaric acid (75.0 mg) at room temperature. After being stirred for several minutes, the mixture was concentrated to 2 ml. The resultant light yellow powder was collected by filtration, washed with diisopropyl ether twice and dried to give (3S)-1,3-dihydro-1-(4-imidazolylmethyl)-3-(2-indolylcarbonylamino) -5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one L-(+)-tartrate (235.3 mg).

Provenance & Evidence