Kojic Acid → 4H-Pyran-4-one, 2-(hydroxymethyl)-5-[(4-methoxyphenyl)methoxy]-

Participants

Reaction Steps

To a solution of 42.6 g kojic acid in 350ml N,N-dimethylformamide, were added 82.8 g anhydrous potassium carbonate and 55 g p-methoxybenzyl chloride, and the mixture was heated at 70°-75° C. for 1.5 hours. The reaction mixture was concentrated to about half its volume, and the concentrate was added to 700 ml water under ice cooling. The precipitate which separated out was collected by filtration, washed with water and ethyl acetate in that order, and dried, giving 59.9 g of 5-p-methoxybenzyloxy-2-hydroxymethyl-4-pyrone.

Provenance & Evidence