Potassium Hydroxide → HCID 15052454, compound

HRID 1073749Notes

Reaction equation

HRID 1073749 reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH2:15][CH2:16][C:17]([O:19]C)=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+]>CO.O>[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH:10]=[CH:11][C:12]=2[O:13][CH3:14])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 15052453HCID 15052453, compound

Product 1

HCID 15052454HCID 15052454, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

To a stirring solution of 0.38 g (1.37 mmol) of methyl 3-(3-cyclopentoxy-4-methoxyphenyl)-n-propanoate in 20 mL of methanol was added dropwise 25 mL of a 1.0 N solution of potassium hydroxide in water over a 5 minute period. The mixture precipitated immediately, but returned to a solution after a 16 hour period at which time the solution was concentrated, diluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid. The analytically pure white solid which formed was collected, washed several times with cold water, and dried in vacuo.

Workup

  1. customThe mixture precipitated immediately
  2. concentrationthe solution was concentrated
  3. additiondiluted with 20 mL of water and neutralized to pH 1.0 with concentrated hydrochloric acid
  4. customThe analytically pure white solid which formed
  5. customwas collected
  6. washwashed several times with cold water
  7. customdried in vacuo

Sources & evidence

ORD record
ord-b5dce72751fe48b5991ee37bf3ced6c7
Source dataset
uspto-grants-1990_11
Patent number
US04971959

Reaction notes

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