N,N-Diethyl-2-piperidinemethanamine → HCID 14075467, compound

HRID 1073770Notes

Reaction equation

HRID 1073770 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6](=[O:19])[NH:7][C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([C:11](=[O:14])[CH2:12]Cl)[C:4]=2[CH:3]=1.[CH2:22]([N:24]([CH2:27][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]1)[CH2:25][CH3:26])[CH3:23]>O1CCOCC1>[Cl:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6](=[O:19])[NH:7][C:8]3[CH:18]=[CH:17][CH:16]=[N:15][C:9]=3[N:10]([C:11](=[O:14])[CH2:12][N:29]3[CH2:30][CH2:31][CH2:32][CH2:33][CH:28]3[CH2:27][N:24]([CH2:25][CH3:26])[CH2:22][CH3:23])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 254287N,N-Diethyl-2-piperidinemethanamineHCID 14075464HCID 14075464, compound

Product 1

HCID 14075467HCID 14075467, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.6 g (0.0174 mole) of 9-chloro-11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one were suspended in 100 ml of anhydrous dioxane and, after addition of 6.0 g (0.035 mol) of 2-[(diethylamino)methyl]piperidine, the mixture was boiled under reflux for 12 hours.

Workup

  1. temperatureunder reflux for 12 hours

Sources & evidence

ORD record
ord-e9cda7394ebd49fe884ed9a7d8113f63
Source dataset
uspto-grants-1990_11
Patent number
US04971966

Reaction notes

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