Acetone → HCID 14699421, compound

Participants

Reaction Steps

In 190 ml of dimethylformamide was dissolved 8 g (79.6 mmol) of the compound (6a). To the solution was added 250 ml of acetone, and 19 ml of 4N Jones' reagent was then added thereto dropwise at room temperature. After the mixture was stirred at room temperature for 30 minutes, 100 ml of methanol and excess sodium hydrogencarbonate were added thereto. The solvent was removed by distillation under reduced pressure. To the residue was added 200 ml of water, and the precipitated crystals were collected by filtration to obtain the entitled compound (II-1) in a yield of 9.7 g (54.5%).

Provenance & Evidence