2-Chloroacetamidine monohydrochloride → HCID 178510535, compound

Participants

Reaction Steps

In 40 ml of 50% aqueous ethanol was dissolved 2.18 g of disodium 4-cyano-3,5-dimercaptoisothiazole, to which 1.29 g of α-chloroacetamidine hydrochloride was added. The mixture was stirred for 2 hours, concentrated under reduced pressure, diluted with water and adjusted to pH 5.2. The precipitating crystals were collected by filtration and washed with water and then ethanol to give 1.23 g of 3-amidinomethylthio-4-cyano-5-mercaptoisothiazole as gray crystals (mp 198°-201° C., decomp.).

Provenance & Evidence