Sodium Hydroxide → HCID 19887612, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-[α-(acetylamino)acetyl]-1-azabicyclo[3.2.1]octane (D29) (0.12 g, 0.57 mmole) and polyphosphoric acid (6.0 g) under nitrogen was placed in an oil bath at 110° C. and heated to 160° C. over a period of 15 min. The temperature was maintained at this level for a further 15 min and the reaction was then poured onto ice. After basifying with 40% sodium hydroxide the solution was saturated with potassium 5 carbonate and extracted into chloroform (4×20 ml). Concentration of the dried (sodium sulphate) organic layers followed by purification on neutral alumina using a graded eluant of 5-10% methanol in ethyl acetate afforded the title compound (E26) as a colourless oil (40mg; 36%).

Provenance & Evidence