Water → 1-(4-Propoxyphenyl)-2-propanone

HRID 1073849ノート

反応式

HRID 1073849 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1.Br[CH2:13][CH2:14][CH3:15].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[CH2:13]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:6][CH:7]=1)[CH2:14][CH3:15]

参加物

6

反応物 4

HCID 962WaterHCID 78401-BromopropaneHCID 11430Potassium CarbonateHCID 70192744-Hydroxyphenylacetone

生成物 1

HCID 150344321-(4-Propoxyphenyl)-2-propanone収率 79.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A suspension of 15.0 g of 1-(4-hydroxyphenyl)-2-propanone, 24.6 g of 1-bromopropane and 13.8 g of potassium carbonate in 100 ml of N,N-dimethylformamide was heated for 4 hours at 65°-70° C. After cooling, the reaction mixture was poured into water and extracted with ether. The extract was washed with water, dried and evaporated. The residue was distilled to give 15.2 g of the desired compound as a pale yellow oil, b.p.136°-138° C. (7 mmHg).

後処理

  1. temperaturewas heated for 4 hours at 65°-70° C
  2. temperatureAfter cooling
  3. extractionextracted with ether
  4. washThe extract was washed with water
  5. customdried
  6. customevaporated
  7. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-d76effe29391474dad3987c18fdedf54
出典データセット
uspto-grants-1990_11
特許番号
US04971990

反応ノート

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