HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene carbonate → 2-(5-Fluoro-2-methoxyphenoxy)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene carbonate | HCID 7303 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-fluoro-2-methoxyphenol | HCID 2774559 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-(5-Fluoro-2-methoxyphenoxy)ethanol | HCID 15079963 | 79.8% |
Reaction Steps
A suspension of 8.75 g of 5-fluoro-2-methoxyphenol, 10.9 g of ethylene carbonate and 8.50 g of potassium carbonate in 12 ml of toluene was refluxed for 2.5 hours. The reaction mixture was diluted with benzene, washed with water, dried and evaporated. The residue was distilled to give 9.15 g of 2-(5-fluoro-2-methoxyphenoxy)ethanol as colorless oil, b.p. 138°-140° C. (8mmHg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971990 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-b9a9945b2083473f800340acad563587 |
| Source note | uspto-grants-1990_11 |