Acetyl chloride → HCID 22157126, compound

HRID 1073860Notes

Reaction equation

HRID 1073860 reaction equation
[CH:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[CH:7]=[C:6]([CH:18]([CH3:20])[CH3:19])[C:5]=1[NH:21][C:22]([NH:24][CH:25]([CH3:27])[CH3:26])=[S:23])([CH3:3])[CH3:2].[C:28]([Cl:31])(=[O:30])[CH3:29]>CC(C)=O>[ClH:31].[CH:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[CH:7]=[C:6]([CH:18]([CH3:20])[CH3:19])[C:5]=1[NH:21][C:22](=[N:24][CH:25]([CH3:27])[CH3:26])[S:23][C:28](=[O:30])[CH3:29])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 22157130HCID 22157130, compound

Product 1

HCID 22157126HCID 22157126, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

7.7 g of N-[2,6-diisopropyl-4-(2-fluorophenoxy)-phenyl]-N'-isopropylthiourea are dissolved in 20 ml of acetone, and 2.36 g of acetyl chloride are added dropwise with stirring at +5° to 10° C. The reaction mixture is subsequently allowed to stand for 3 hours at +10° C. The product which has crystallized out is filtered off with suction, washed with a little acetone and dried in vacuo. The title compound of the formula ##STR9## is present in the form of colourless crystals; melting point 164° C. with decomposition.

Workup

  1. customThe product which has crystallized out
  2. filtrationis filtered off with suction
  3. washwashed with a little acetone
  4. customdried in vacuo

Sources & evidence

ORD record
ord-f6ecfdb5e6cf41848636253a155cb118
Source dataset
uspto-grants-1990_11
Patent number
US04971994

Reaction notes

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