4-[1,1-Dimethyl-3-(2-pyridyl)-2-propynyloxy]benzonitrile → 2,2-dimethyl-4-(2-pyridyl)-2H-1-benzopyran-6-carbonitrile

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Reaction Steps

12 98 g of 4-[1,1-dimethyl-3-(2-pyridyl)-2-propynyloxy]benzonitrile were dissolved in 50 ml of 1,2-dichlorobenzene and heated at reflux for 5 hours. After cooling the mixture was evaporated. The residue was chromatographed on silica gel using ethyl acetate/petroleum ether (1:2), ethyl acetate/petroleum ether (1:1) and ethyl acetate for the elution. There were obtained 6.5 g of 2,2-dimethyl-4-(2-pyridyl)-2H-1-benzopyran-6-carbonitrile of melting point 106-108° C. after recrystallization from cyclohexane.

Provenance & Evidence