6-[5-Cyano-2-hydroxy-alpha-(2-methylpropenyl)benzyl]pyrimidine 1-oxide → 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrimidine 1-oxide
Reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:21])=[C:7]([CH:20]=1)[CH:8]([C:13]1[N+:18]([O-:19])=[CH:17][N:16]=[CH:15][CH:14]=1)[CH:9]=[C:10]([CH3:12])[CH3:11])#[N:2]>C(OCC)(=O)C.CCCCCC>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:21][C:10]([CH3:12])([CH3:11])[CH2:9][CH:8]([C:13]3[N+:18]([O-:19])=[CH:17][N:16]=[CH:15][CH:14]=3)[C:7]=2[CH:20]=1)#[N:2]Participants
3
Procedure
In an analogous manner to that described in the first paragraph of Example 8, from 0.22 g of 6-[5-cyano-2-hydroxy-α-(2-methylpropenyl)benzyl]pyrimidine 1-oxide there was obtained 0.01 g of 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrimidine 1-oxide in the form of an off-white solid (from ethyl acetate/n-hexane).
Sources & evidence
- ORD record
- ord-433a53efd68d47c392411ed08dec9ff7
- Source dataset
- uspto-grants-1990_11
- Patent number
- US04971982
Reaction notes
Loading…