4-[1,1-Dimethyl-3-(2-quinolyl)-2-propynyloxy]benzonitrile → 2,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile

참여 물질

반응 단계

5.8 g of 4-[1,1-dimethyl-3-(2-quinolyl)-2-propynyloxy]benzonitrile were heated at reflux for 2 hours in 50 ml of dichlorobenzene. The mixture was allowed to cool to room temperature and was then evaporated to dryness. The residue was chromatographed on silica gel using ethyl acetate/petroleum ether (1:3) for the elution. The product was recrystallized from isopropanol to give 2.1 g of 2,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile of melting point 102°-104° C.

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