HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 19895647, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Iodopyridine | HCID 70714 | — |
| Reactant | 4-[(2-Methylbut-3-yn-2-yl)oxy]benzonitrile | HCID 2779072 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Diethylamine | HCID 8021 | — |
| Product | HCID 19895647 | HCID 19895647 | — |
Reaction Steps
10.25 g of 3-iodopyridine were added at to a solution of 44 mg of palladium(II) chloride, room temperature 131 mg of triphenylphosphine and 95 mg of copper(I) iodide in 200 mg of diethylamine 9.25 g of 4-(1,1-dimethyl-2-propynyloxy)benzonitrile were then added and the mixture was stirred for 3 days. The mixture was evaporated and the residue was partitioned between ethyl acetate and water. The organic phase was dried over sodium sulphate and evaporated. The residue was chromatographed on silica gel using ethyl acetate/petroleum ether (11:9) for the elution to give 11.8 g of 4-[1,1-dimethyl-3-(3-pyridyl)-2-propynyloxy]benzonitrile in the form of an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971982 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-222372a8b5f64169bb8e1d385375dbc6 |
| Source note | uspto-grants-1990_11 |