Hydrochloric Acid → Benzyl L-valyl-L-prolinate hydrochloride

Participants

Reaction Steps

N-t-butyloxycarbonyl-L-valyl-L-proline benzylester (16.32 g, 40 mmole) was dissolved in 4N hydrochloric acid in dioxane (100 ml) solution, and the solution was stirred for 1 hour at room temperature. The solvent was distilled off and the residue thus obtained was powdered in diethyl ether to give L-valyl-L-proline benzylester hydrochloride (yield 10.31 g, 75.6%).

Provenance & Evidence