HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → L-isoleucyl-L-proline benzylester hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Boc-Ile-Pro-OBzl | HCID 14306235 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | L-isoleucyl-L-proline benzylester hydrochloride | HCID 14306240 | 92.9% |
Reaction Steps
N-t-butyloxycarbonyl-L-isoleucyl-L-proline benzylester (39.76 g, 95 mmole) was dissolved in 4N hydrochloric acid in dioxane (360 ml), and stirred for 30 minutes at room temperature. The solvent was distilled and the residue thus obtained was powdered in diethyl ether to obtain L-isoleucyl-L-proline benzylester hydrochloride(yield: 31.31 g, 92.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971993 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-2bb9f746c0874a6a9cb3d38a698c4c84 |
| Source note | uspto-grants-1990_11 |