Hydrochloric Acid → HCID 14858850, compound

Participants

Reaction Steps

N-benzenesulfonyl-L-isoleucyl-L-proline benzylester (1.96 g, 4.3 mmole) was dissolved in methanol 40 ml ), and water (5 ml) solution of sodium bicarbonate (0.42 g, 5 mmole) was added thereto. Hydrogen gas was passed through the solution in the presence of 5% palladium-carbon as a catalyst for 3 hours. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure and the residue thus obtained was dissolved in water (20 ml), methylene chloride (100 ml) was added thereto, and at least 1N aqueous hydrochloric acid (10 ml) was added thereto while vigorous stirring. The methylene chloride layer was taken and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue thus obtained was recrystallized from ethyl acetate and petroleum ether to give N-benzenesulfonyl-L-isoleucyl-L-proline (yield: 1.16 g, 73.7%).

Provenance & Evidence