HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3',4'-dihydroxyacetophenone → 3',4'-Dihydroxy-2-(methylthio)acetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | HCID 18968240 | HCID 18968240 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3',4'-Dihydroxy-2-(methylthio)acetophenone | HCID 13718339 | — |
Reaction Steps
The procedure is as in Example 4 for the preparation of α-methylthioacetophenone, starting with a stirred solution of 4-(2-chloroacetyl)pyrocatechol (18.6 g) in methanol (200 cc). Sodium methanethiolate (7 g) is added in the course of 15 minutes at a temperature in the region of 20° C., and the mixture is left with stirring for 3 hours at the same temperature. 4-[2-(Methylthio)acetyl]pyrocatechol (14.5 g), m.p. 107° C., is thereby obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04971979 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-745b1e2c84bc4c479404a27dd4b7b2fb |
| Source note | uspto-grants-1990_11 |