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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1074057Generated: October 27, 2026

Ethyl Thioglycolate → Ethyl (3-phenoxybenzylthio)acetate

https://huagongshe.com/reaction/1074057

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl ThioglycolateHCID 12185—
Reactant1-(Chloromethyl)-4-phenoxybenzeneHCID 520994—
ReactantSodium ethoxideHCID 2723922—
ReactantEthyl (4-methylbenzylthio)acetateHCID 4107274—
SolventEthanolHCID 702—
ProductEthyl (3-phenoxybenzylthio)acetateHCID 53984256—

Reaction Steps

The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 1-chloromethyl-4-phenoxybenzene (21.5 g), a 2M ethanolic solution of sodium ethylate (50 cc) and ethyl 2-mercaptoacetate (12.2 g) in ethanol (200 cc). Ethyl (3-phenoxybenzylthio)acetate (28.8 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04971979
Source datasetuspto-grants-1990_11
ORD IDord-31facc416b20404fa2052b44a83341a5
Source noteuspto-grants-1990_11