Sulfuric Acid → Ethyl (3-benzoylphenyl)acetate

HRID 1074073Notes

Reaction equation

HRID 1074073 reaction equation
O([C:8]1[CH:9]=[C:10]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:11]=[CH:12][CH:13]=1)C1C=CC=CC=1.[C:20](C1C=C(CC(O)=O)C=CC=1)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.S(=O)(=O)(O)O>C(O)C>[C:20]([C:8]1[CH:9]=[C:10]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:11]=[CH:12][CH:13]=1)(=[O:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 30931(3-Benzoylphenyl)acetic acidHCID 12509092Ethyl (3-phenoxyphenyl)acetate

Product 1

HCID 53948061Ethyl (3-benzoylphenyl)acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The procedure is as in Example 33 for the preparation of ethyl (3-phenoxyphenyl)acetate, starting with (3-benzoylphenyl)acetic acid (16.6 g) and 36N aqueous sulphuric acid solution (2 cc) in ethanol (200 cc). Ethyl (3-benzoylphenyl)acetate (16.8 g) is obtained in the form of a brown oil, and is used in the crude state in the subsequent syntheses.

Sources & evidence

ORD record
ord-fd3c4c5eb15940fbadbe253e9b2d3205
Source dataset
uspto-grants-1990_11
Patent number
US04971979

Reaction notes

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