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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1074078Generated: October 25, 2026

Ethyl Thioglycolate → Ethyl (4-isopropylbenzylthio)acetate

https://huagongshe.com/reaction/1074078

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl ThioglycolateHCID 12185—
Reactant1-(Bromomethyl)-4-(propan-2-yl)benzeneHCID 47719—
ReactantSodium ethoxideHCID 2723922—
ReactantEthyl (4-methylbenzylthio)acetateHCID 4107274—
SolventEthanolHCID 702—
ProductEthyl (4-isopropylbenzylthio)acetateHCID 54329641—

Reaction Steps

The procedure is as in Example 29 for the preparation of ethyl (4-methylbenzylthio)acetate, starting with 1-bromomethyl-4-isopropylbenzene (15 g), a 2M ethanolic solution of sodium ethylate (49 cc) and ethyl 2-mercaptoacetate (9.8 g) in ethanol (150 cc). Ethyl (4-isopropylbenzylthio)acetate (17.9 g) is thereby obtained, and is used in the crude state in the subsequent syntheses.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04971979
Source datasetuspto-grants-1990_11
ORD IDord-8fab29ac3da94763bba07874509706d5
Source noteuspto-grants-1990_11