Phenol → Diglycidyl ether

Participants

Reaction Conditions

Reaction Steps

The starting phenol derivative (13 g) of the following formula: ##STR35## and the same R-(-)-epichlorohydrin (13.2 g) as used in Preparation 3, potassium t-butoxide (8.8 g) and t-butyl alcohol (80 ml) are mixed and stirred at 60° C. for 2 hours. After the reaction mixture is concentrated, chloroform is added to the concentrate and the resultant is washed with a saturated saline solution and dried over anhydrous magnesium sulfate. Chloroform is distilled away under reduced pressure to give a crude product. The crude product is purified by silica gel column chromatography to give S isomer of a glycidyl ether (14.2 g) of the following formula: ##STR36##

Provenance & Evidence