Phenol → Diglycidyl ether

Participants

Reaction Steps

A mixture of the starting phenol derivative (10 g) of the following formula: ##STR41## the same R-(-)-epichlorohydrin (16.07 g) as used in Preparation 3, 20 wt. % aqueous sodium hydroxide (7.33 g) and dimethylformamide (20 ml) is heated with stirring at 60°-70° C. for one hour. The reaction mixture is cooled and thereto is added water. The mixture is extracted with dichloromethane to obtain a crude product (11.67 g). The crude product is purified by silica gel column chromatography to give S isomer of a glycidyl ether (9.07 g) of the following formula: ##STR42##

Provenance & Evidence