Methyl iodide → HCID 136404526, compound

Participants

Reaction Steps

To a mixture of 2-nitroiminohexahydropyrimidin-5-yl diphenylacetate (0.4 g) and methyl iodide (0.16 g) in DMF (4 ml), 80% sodium hydride (0.06 g) was added. The mixture was then stirred at room temperature overnight. The solvent was removed and the residue taken up with methylene chloride/water. The organic layer was evaporated and the residue was purified by column chromatography (eluent methylene chloride/methanol 98:2) to afford 1-methyl-2-nitroiminohexahydropyrimidin-5-yl diphenylacetate. M.p. 187° C.

Provenance & Evidence