HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → 2-(2-Pyrimidyl)aminoethyl alpha-cyclohexylphenylglycolate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | (+-)-Cyclohexylphenylglycolic acid | HCID 97700 | — |
| Reactant | 2-(Pyrimidin-2-ylamino)ethanol | HCID 572714 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(2-Pyrimidyl)aminoethyl alpha-cyclohexylphenylglycolate | HCID 22155868 | — |
Reaction Steps
To a mixture of α-cyclohexylphenylglycolic acid (1 g) and N,N-carbonyldiimidazole (0.69 g) in DMF (10 ml), 2-(2-hydroxyethyl) aminopyrimidine (0.6 g) and DBU (0.65 g) were added. The mixture was treated according to the method described in Example 3a, affording 2-(2-pyrimidyl)aminoethyl α-cyclohexylphenylglycolate, which was heated with ethanolic HCl to afford 1,5 g of the hydrochloride. M.p. 167°-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04973592 |
| Source dataset | uspto-grants-1990_11 |
| ORD ID | ord-c5cb22826df543c895d84be9fa23a3b8 |
| Source note | uspto-grants-1990_11 |