HCID 22155922, compound → HCID 22155920, compound

HRID 1074157Notes

Reaction equation

HRID 1074157 reaction equation
[ClH:1].[CH:2]1([C:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([OH:21])[C:9]([O:11][CH2:12][CH2:13][NH:14][C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)=[O:10])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>[Pd].O>[ClH:1].[CH:22]1([C:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)([OH:21])[C:9]([O:11][CH2:12][CH2:13][NH:14][C:15]2[NH:20][CH2:19][CH2:18][CH2:17][N:16]=2)=[O:10])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1

Participants

4

Reactant 1

HCID 22155922HCID 22155922, compound

Product 1

HCID 22155920HCID 22155920, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of 2-(2-pyrimidyl)aminoethyl α-cyclohexylphenylglycolate hydrochloride (1.4 g) and 10% palladium on carbon (0.15 g) in H2O (150 ml), was hydrogenated at room pressure. After the absorption had ceased, the catalyst was filtered off, and the solution was evaporated in vacuo. The residue was triturated with ethylacetate, affording 0.85 of 2-(1,4,5,6-tetrahydropyrimidin-2-yl)aminoethyl α-cyclohexylphenylglycolate hydrochloride. M.p. 95° C.

Workup

  1. customAfter the absorption
  2. filtrationthe catalyst was filtered off
  3. customthe solution was evaporated in vacuo
  4. customThe residue was triturated with ethylacetate

Sources & evidence

ORD record
ord-b97202b88f824dfc8e37de7d68824075
Source dataset
uspto-grants-1990_11
Patent number
US04973592

Reaction notes

Loading…