Sodium Chloride → HCID 22155919, compound

Participants

Reaction Steps

To a stirred and ice-cooled solution of cyclohexyl magnesium chloride (60 mmol) in dry ether (23.2 ml), 4-chlorobutyrophenone (5.5 g) in ether (17 ml) was added dropwise. The mixture was stirred at 0° C. for 2 hours, then an aqueous solution of sodium chloride was cautiously added. The organic phase was separated and dried. The solvent was removed and the residue was purified by column chromatography (hexane, ether 98:2), affording 5 g of 1-phenyl-1-cyclohexyl-4-chloro-1-butanol as an oil.

Provenance & Evidence