HCID 14459252, compound → HCID 14459254, compound

HRID 1074168Notes

Reaction equation

HRID 1074168 reaction equation
[ClH:1].[CH2:2]([N:9](C)[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)=[O:12])C1C=CC=CC=1>[Pd].C(O)(=O)C>[ClH:1].[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:11](=[O:12])[CH2:10][NH:9][CH3:2])=[CH:18][CH:17]=1

Participants

4

Reactant 1

HCID 14459252HCID 14459252, compound

Product 1

HCID 14459254HCID 14459254, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

1.2 g of 10% palladium on charcoal is added under a nitrogen atmosphere to a solution of 10 g (31 mmol) of the compound from Example 1 in 200 ml of glacial acetic acid. After hydrogenation in a shaking apparatus (hydrogen uptake about 700 ml), the catalyst is filtered off, the solvent is removed by distillation and the product is washed with water and dried.

Workup

  1. filtrationAfter hydrogenation in a shaking apparatus (hydrogen uptake about 700 ml), the catalyst is filtered off
  2. customthe solvent is removed by distillation
  3. washthe product is washed with water
  4. customdried

Sources & evidence

ORD record
ord-40c4c04a56dd45c79b7630639b9f99ec
Source dataset
uspto-grants-1990_11
Patent number
US04973598

Reaction notes

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