2,2,2-Trifluoroethanol → HCID 14622036, compound

Participants

Reaction Steps

3.0 g (0.011 mol) 2-(4-Ethoxy-3-fluorophenyl)-3,3-dimethylbutyryl chloride was added dropwise to a solution of 1.12 g (0.0121 mol) 2,2,2-trifluoroethanol and 100 mg 4-dimethylaminopyridine in 15 ml pyridine at 0° C. After stirring for two hours at room temperature, tlc showed complete reaction. The mixture was added to ice/water, made weakly acidic, extracted with ether, the extract dried over magnesium sulphate and evaporated under reduced pressure. After silica gel chromatography, 2.80 g (=75.6% of theory) of a pale yellow oil was obtained. nD20 : 1.4783

Provenance & Evidence