反应详情

30 g of 1-(difluoromethoxy)-4-(tert.-butoxy)benzene from Example 4a), 200 ml of ethanol, 50 ml of water and 10 ml of concentrated sulfuric acid were stirred at 80° C. for 2 hours. The reaction mixture was extracted with ether, the organic phase was dried and filtered, and the filtrate was concentrated to give 16 g of 4-difluoromethoxyphenol.

1. extractionThe reaction mixture was extracted with ether
2. customthe organic phase was dried
3. filtrationfiltered
4. concentrationthe filtrate was concentrated