Bromine → 1-Bromo-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

HRID 1074307Notes

Reaction equation

HRID 1074307 reaction equation
[CH3:1][C:2]([CH3:12])([CH3:11])[C:3](=[O:10])[CH2:4][N:5]1[CH:9]=[N:8][CH:7]=[N:6]1.[Br:13]Br>>[Br:13][CH:4]([N:5]1[CH:9]=[N:8][CH:7]=[N:6]1)[C:3](=[O:10])[C:2]([CH3:12])([CH3:11])[CH3:1]

Participants

3

Reactant 2

HCID 24408BromineHCID 1008773,3-Dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone

Product 1

HCID 130216491-Bromo-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Procedure

Thus, for example, 3,3-dimethyl-1-(4-methoximino- methyl-phenoxy)-1-(1,2,4-triazol-1-yl)-butan-2-one of the formula ##STR10## can be prepared by a process in which 3,3-dimethyl-1(1,2,4-triazol-1-yl)-butan-2-one is first reacted with bromine to give 1-bromo-(1,2,4-triazol-1-yl)-3,3-dimethyl- butan-2-one and this is then reacted with 4-hydroxybenzaldehyde O-methyl-oxime ether in the presence of a base. This synthesis can be illustrated by an equation as follows: ##STR11##

Sources & evidence

ORD record
ord-81c031ebef9c4ba0a5a8b7aff2e90043
Source dataset
uspto-grants-1990_11
Patent number
US04973753

Reaction notes

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