Chloroform → HCID 14346304, compound

HRID 1074308Notes

Reaction equation

HRID 1074308 reaction equation
C(Cl)(Cl)Cl.[CH3:5][CH2:6]/[C:7](/[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[C:8](/[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[CH:18][CH:17]=1)\[C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1>CC(C)=O>[CH3:5][CH2:6]/[C:7](/[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[C:8](/[C:16]1[CH:21]=[CH:20][C:19]([O:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])=[CH:18][CH:17]=1)\[C:9]1[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=1.[CH3:11][C:12]([CH3:13])=[O:15]

Participants

4

Reactant 2

HCID 6212ChloroformHCID 449459(Z)-4-Hydroxytamoxifen

Product 1

HCID 14346304HCID 14346304, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

0.1 mol of the chloroform or perchloroethylene complex of Z-4-hydroxytamoxifen from Examples (1c1) and (1c2) are recrystallized from 300 ml of acetone and suction filtered at 10° C.

Workup

  1. filtrationfiltered at 10° C.

Sources & evidence

ORD record
ord-4099fa1a601d42f5ac75158296d6e2d3
Source dataset
uspto-grants-1990_11
Patent number
US04973755

Reaction notes

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